4A (Expenses $ 585568660 including grants of $ 145946) (Revenue $ 0)
RESEARCH: THE CURRENT BASIC SCIENCE AND CLINICAL RESEARCH AT THE HOSPITAL INCLUDES WORK IN GENE THERAPY, CHEMOTHERAPY, THE BIOCHEMISTRY OF NORMAL AND CANCEROUS CELLS, RADIATION TREATMENT, BLOOD DISEASES, RESISTANCE TO THERAPY, VIRUSES, NEUROLOGICAL DISEASES, HEREDITARY DISEASES, INFLUENZA, PEDIATRIC AIDS AND PHYSIOLOGICAL EFFECTS OF CATASTROPHIC ILLNESSES.

4B (Expenses $ 551616643 including grants of $ 16098) (Revenue $ 123359776)
PATIENT CARE: THE HOSPITAL PROVIDED 17,175 INPATIENT DAYS OF CARE DURING THE YEAR. OUR BONE MARROW TRANSPLANTATION PROGRAM ACCOUNTED FOR 4,028 OR 23% OF THOSE INPATIENT DAYS. PATIENTS MADE 70,337 CLINIC REGISTRATIONS DURING THE YEAR.

4C (Expenses $ 49067556 including grants of $ 1064110) (Revenue $ 0)
EDUCATION AND TRAINING: AS PART OF ITS MISSION, THE HOSPITAL HAS DEVELOPED A GLOBAL INITIATIVE (ST. JUDE GLOBAL) TO IMPROVE THE SURVIVAL RATES OF CHILDREN WITH CANCER AND OTHER CATASTROPHIC DISEASES WORLDWIDE. ST. JUDE GLOBAL ACCOMPLISHES THIS BY SHARING KNOWLEDGE, TECHNOLOGY AND ORGANIZATIONAL SKILLS, HELPING TO IMPLEMENT NEW APPROACHES TO TREAT PEDIATRIC CANCER GLOBALLY, AND DEVELOPING REGIONAL NETWORKS COMMITTED TO ERADICATING CANCER IN CHILDREN. THIS MISSION WILL BE ACHIEVED BY FOCUSING ON THREE OVERRIDING GOALS: (1) TO TRAIN THE CLINICAL WORKFORCE THAT WILL BE REQUIRED TO MEET OUR MISSION, (2) TO DEVELOP AND STRENGTHEN HEALTH SYSTEMS AND PATIENT-CENTERED INITIATIVES THAT ENCOMPASS THE ENTIRE CONTINUUM OF CARE REQUIRED FOR CHILDREN WITH CANCER AND NON-MALIGNANT HEMATOLOGICAL (CONTINUED ON SCHEDULE O) DISEASES, AND (3) TO ADVANCE KNOWLEDGE IN GLOBAL PEDIATRIC ONCOLOGY AND HEMATOLOGY THROUGH RESEARCH TO SUSTAIN A CONTINUOUS IMPROVEMENT IN THE LEVEL AND QUALITY OF CARE DELIVERED AROUND THE GLOBE. THESE INITIATIVES ARE SPEARHEADED BY ST. JUDE EXPERTS WHO WORK CLOSELY WITH HEALTHCARE PROFESSIONALS AT OUR PARTNER SITES. IN ADDITION, A GRADUATE PROGRAM AT THE DOCTORAL AND MASTER'S LEVEL IS OFFERED THROUGH A WHOLLY-OWNED SUBSIDIARY, ST. JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, LLC, TO EDUCATE AND TRAIN FUTURE GENERATIONS OF SCIENTISTS SEEKING TO UNDERSTAND THE MOLECULAR BASIS OF HUMAN DISEASE AND DEVELOP NOVEL THERAPIES BASED ON THAT UNDERSTANDING.

ST. JUDE CHILDREN'S RESEARCH HOSPITAL
PART V, SECTION B, LINE 5: THE FISCAL YEAR 2022 CHNA BUILDS UPON THE FISCAL YEAR 2019 CHNA AND REFLECTS THE ACTIVITIES IDENTIFIED IN THE FISCAL YEAR 2019 COMMUNITY BENEFIT IMPLEMENTATION PLAN FOR ST. JUDE. THE FISCAL YEAR 2022 CHNA WAS LED BY AN INTERNAL TEAM OF ST. JUDE STAFF MEMBERS. THE LEADERSHIP OF THIS TEAM ENGAGED HEALTH RESOURCES IN ACTION (HRIA), A NON-PROFIT PUBLIC HEALTH CONSULTANCY ORGANIZATION, TO CONDUCT THE CHNA. TO DEVELOP A SOCIAL, ECONOMIC, AND HEALTH PORTRAIT OF THE COMMUNITY SERVED BY ST. JUDE, HRIA REVIEWED EXISTING DATA DRAWN FROM ST. JUDE, LOCAL, STATE, AND NATIONAL SOURCES. IN ADDITION TO ANALYZING QUANTITATIVE DATA, HRIA CONDUCTED QUALITATIVE RESEARCH WITH INTERNAL AND EXTERNAL ST. JUDE STAKEHOLDERS AS WELL AS FAMILY MEMBERS AND FORMER PATIENTS IN ORDER TO SUPPLEMENT QUANTITATIVE FINDINGS WITH PERCEPTIONS OF COMMUNITY STRENGTHS AND ASSETS, PRIORITY HEALTH CONCERNS, AND SUGGESTIONS FOR FUTURE PROGRAMMING AND SERVICES.FOCUS GROUPS WERE CONDUCTED WITH CURRENT AND FORMER ST. JUDE PATIENTS, PATIENT CAREGIVERS, AND ST. JUDE CLINICAL, RESEARCH, AND ADMINISTRATIVE STAFF. DIFFERENT TOPIC AREAS WERE EXPLORED BASED ON THE UNIQUE EXPERIENCES OF EACH OF THE GROUPS.HRIA CONDUCTED 27 INTERVIEWS WITH 34 INDIVIDUALS; 13 INTERVIEWS WERE CONDUCTED WITH 19 STAFF OF ST. JUDE HOSPITAL, AND 12 INTERVIEWS WERE CONDUCTED WITH INDIVIDUALS FROM OUTSIDE THE ORGANIZATION. INTERVIEW PARTICIPANTS REPRESENTED A RANGE OF SECTORS, INCLUDING LEADERS IN HEALTH CARE AND HEALTH RESEARCH, GOVERNMENT, AND SOCIAL SERVICE ORGANIZATIONS FOCUSING ON VULNERABLE POPULATIONS. ADDITIONALLY, TWO INTERVIEWS WERE CONDUCTED WITH TWO FORMER ST. JUDE PATIENTS. EXTERNAL KEY INFORMANT INTERVIEWS WERE CONDUCTED WITH PEDIATRICS EAST, THE UNIVERSITY OF MEMPHIS, SCHOOL OF PUBLIC HEALTH, CHRIST COMMUNITY HEALTH SERVICES, LE BONHEUR CHILDREN'S HOSPITAL, TENNESSEE DEPARTMENT OF HEALTH, SHELBY COUNTY HEALTH DEPARTMENT, CHURCH HEALTH, AND SHELBY COUNTY GOVERNMENT.

ST. JUDE CHILDREN'S RESEARCH HOSPITAL
PART V, SECTION B, LINE 13H: NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. ALL PATIENTS ARE ELIGIBLE TO RECEIVE MEDICAL CARE AND SUPPORT SERVICES AT NO COST. THERE ARE NO TESTS OR THRESHOLDS APPLIED TO DETERMINE ELIGIBILITY FOR FINANCIAL ASSISTANCE. ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE REGARDLESS OF THEIR ABILITY TO PAY.

ST. JUDE CHILDREN'S RESEARCH HOSPITAL
PART V, SECTION B, LINE 15E: NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. ALL PATIENTS ARE ELIGIBLE TO RECEIVE MEDICAL CARE AND SUPPORT SERVICES AT NO COST. THERE ARE NO TESTS OR THRESHOLDS APPLIED TO DETERMINE ELIGIBILITY FOR FINANCIAL ASSISTANCE. ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE REGARDLESS OF THEIR ABILITY TO PAY.

ST. JUDE CHILDREN'S RESEARCH HOSPITAL
PART V, SECTION B, LINE 20E: ST. JUDE DOES NOT TAKE ANY OF THE COLLECTION ACTIONS DESCRIBED IN PART V, SECTION B, LINE 19 BECAUSE ST. JUDE COVERS ALL TREATMENTS, COPAYS, DEDUCTIBLES, COINSURANCE AND ANY OTHER COST SHARING OBLIGATIONS THAT ARE NOT COVERED BY INSURANCE. ST. JUDE TAKES NO ACTION TO COLLECT FROM PATIENTS OR THEIR FAMILIES AND DOES NOT REPORT TO CREDIT AGENCIES.

ST. JUDE CHILDREN'S RESEARCH HOSPITAL:
PART V, SECTION B, LINE 11: ST. JUDE CHILDREN'S RESEARCH HOSPITAL CONDUCTED AND ADOPTED ITS FOURTH COMMUNITY HEALTH NEEDS ASSESSMENT (CHNA) DURING TAX YEAR 2021 AND INTENDS TO ADDRESS THE FOLLOWING SIGNIFICANT HEALTH NEEDS, LISTED IN ORDER OF PRIORITY: AIM 1: IMPROVING ACCESS TO MENTAL HEALTH SUPPORTS AND SERVICES IN THE COMMUNITY, BEYOND THOSE RELATED TO PATIENT DIAGNOSIS AND TREATMENT. AIM 2: IMPROVING ACCESS TO PROVIDERS, RESOURCES, AND COORDINATED CARE DURING THE TRANSITION OF CARE FROM ST. JUDE AND ITS AFFILIATES TO COMMUNITY AND/OR ADULT CARE.AIM 3: IMPROVING ACCESS AND EQUITY TO CLINICAL TRIALS AT ST. JUDE AND ITS AFFILIATES.AIM 4: CONDUCTING CANCER PREVENTION WORK THROUGH EDUCATION AND HPV VACCINATION.AIM 5: INCREASING AWARENESS AND EDUCATION OF SICKLE CELL DISEASE AND INFECTIOUS DISEASES (HIV/AIDS) IN THE COMMUNITY.AIM 6: STRENGTHEN COMMUNITY PARTNERSHIPS IN THE GREATER MEMPHIS AREA TO ADDRESS SOCIAL DETERMINANTS OF HEALTH FOR LOCAL PATIENTS.CUTTING ACROSS ALL OF THESE AIMS IS THE COMMITMENT TO ADDRESS EQUITY AND TO IDENTIFY OPPORTUNITIES FOR COLLABORATION. GIVEN ITS FOCUSED MISSION AND MODEL OF PROVIDING SPECIALIZED SERVICES TO CHILDREN IN CRISIS, ST. JUDE DOES NOT HAVE THE CAPACITY OR RESOURCES TO MEET ALL NEEDS OF ALL CHILDREN AND THEIR FAMILIES. HOWEVER, STRATEGIC PARTNERSHIPS WITH OTHER HEALTHCARE PROVIDERS AND WITH SCHOOLS AND COMMUNITY-BASED ORGANIZATIONS ALLOW ST. JUDE TO CREATE A NETWORK OF RESOURCES THAT CAN BE LEVERAGED TO MEET THE HEALTH AND SOCIAL NEEDS OF A WIDER COMMUNITY OF PATIENTS AND THEIR FAMILIES.THIS CHNA WAS CONDUCTED AND ADOPTED AT THE END OF TAX YEAR 2021; THEREFORE, THESE HEALTH NEEDS WILL BE ADDRESSED OVER THE THREE TAX YEARS, 2022 - 2024.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. DID TAKE THE FOLLOWING ACTIONS DURING TAX YEAR 2021 WITH RESPECT TO THE CHNA CONDUCTED IN 2018:AIM #1 IMPROVING ACCESS TO CAREHEALTH NEED IDENTIFIED: IMPROVING ACCESS TO CARE - PALLIATIVE CARESTRATEGY 1. RECRUIT AND TRAIN FIVE PHYSICIAN FELLOWS IN THE PALLIATIVE CARE TRAINING PROGRAM, 2 PEDIATRIC FELLOWS, 3 ADULT/MED-PEDS FELLOWS.STRATEGY 2. PROVIDE TRAINING IN PALLIATIVE CARE FOR HEALTHCARE PERSONNEL THROUGH TARGETED CONFERENCES AND OTHER EDUCATIONAL OPPORTUNITIES INCLUDING END-OF-LIFE NURSING EDUCATION CONSORTIUM (ELNEC) CONFERENCE, A REGIONAL ELNEC OFFERING FOR OUR REGIONAL HOSPICE AND PALLIATIVE CARE NURSES, AN INSTITUTION-DEVELOPED QUALITY OF LIFE SEMINAR (QOLA), AND A 1-DAY REGIONAL PEDIATRIC ONCOLOGY PALLIATIVE CARE CONFERENCE.STRATEGY 3. EDUCATE COMMUNITY PROVIDERS ABOUT PALLIATIVE CARE MEDICINE (PCM) THROUGH COMMUNITY-BASED BRIDGING PROGRAMS FOR HOME HEALTH AND HOSPICE CARE THROUGH THE QUALITY OF LIFE FOR ALL KIDS PROGRAM VIA A THREE-HOUR DIDACTIC CURRICULUM.STRATEGY 4. ENHANCE TRAINING OPPORTUNITIES WITH ST. JUDE AFFILIATES.ACTIONS TAKEN: - HOSTED A VIRTUAL PEDIATRIC PALLIATIVE ONCOLOGY SYMPOSIUM (PPOS) WITH FREE REGISTRATION; APPROXIMATELY 1800 PARTICIPANTS IN THE EVENT. - EXPANDED AFFILIATE-BASED BEREAVEMENT SUPPORT THROUGH QOLA GRIEF AND BEREAVEMENT PROGRAM.HEALTH NEED IDENTIFIED: SERVICES AND RESOURCES FOR CAREGIVERSSTRATEGY 1. DEVELOP AN INSTITUTIONAL PARENT MENTAL HEALTH TASK FORCE WITH REPRESENTATION FROM RELEVANT SERVICES.STRATEGY 2. INTRODUCE NINA ANTONIOTTI, DIRECTOR OF INTEROPERABILITY AND PATIENT ENGAGEMENT, TO THE TELEHEALTH SUBCOMMITTEE OF THE PARENT MENTAL HEALTH TASK FORCE.STRATEGY 3. DEVELOP CRITERIA FOR TELE-MENTAL HEALTH AND OUTCOMES OF THE PROGRAM.STRATEGY 4. WRITE AN RFP, INCLUDING FEEDBACK FROM DEPARTMENT OF PSYCHOLOGY AND SOCIAL WORK.STRATEGY 5. SEND OUT REQUEST FOR PROPOSALS, TO BE RETURNED BY MAY 28, 2019.STRATEGY 6. SELECTION OF COMPANIES FOR ONSITE DEMONSTRATIONS WITH SUBCOMMITTEE.STRATEGY 7. SELECTION OF FINAL TELE-MENTAL HEALTH COMPANY.STRATEGY 8. REVIEW OF ARCADIAN TELEPSYCHIATRY SERVICE AGREEMENT BY ST. JUDE LEGAL SERVICES.STRATEGY 9. BEGIN WORKFLOW DOCUMENTATION FOR REFERRALS, INCLUDING PROCESS FOR CAREGIVERS HAVING PRESCRIPTIONS FILLED AT THE ST. JUDE PHARMACY.ACTIONS TAKEN: - CONDUCTED A MARKET SURVEY AND SELECTED A NEW TELEMENTAL HEALTH PROVIDER, WELLNITE, THAT MEETS MANY OF THE OBJECTIVES AND OUTCOMES LISTED ABOVE. - PROVIDED SAME DAY THERAPIST SERVICES FOR CAREGIVERS WHO NEED THERAPY AND BEREAVEMENT OR HOSPICE SUPPORT. - INCREASED THE NUMBER OF REFERRALS SIGNIFICANTLY OVER THE LAST TWO YEARS' VOLUMES. - CONTRACTED FOR A LOCAL PSYCHIATRIST WHO CAN SEE CAREGIVERS WITHIN 48 HOURS OF REFERRAL WHO NEED CONTROLLED SUBSTANCE MEDICATION MANAGEMENT. AIM #2 IMPROVING COORDINATION OF CAREHEALTH NEED IDENTIFIED: TRANSITION OF PATIENTS FROM PEDIATRIC TO ADULT HEALTHCARE - SICKLE CELLSTRATEGY 1. CONTINUE TO WORK WITH ADULT SICKLE CELL CENTERS IN THE COMMUNITY TO ENHANCE A SEAMLESS TRANSITION FROM PEDIATRIC CARE.STRATEGY 2. ENHANCE ADOLESCENT AND YOUNG ADULTS (AYA) TRANSITION CLINICS WITH CO-LOCATION OF PEDIATRIC AND ADULT HEMATOLOGY PROVIDERS.STRATEGY 3. AUGMENT FORMAL PROGRAMMING AND PLANNING PROCESSES FOR ADOLESCENTS WITH HEMATOLOGIC AND ONCOLOGIC DISEASES, THROUGH DEVELOPMENT OF DISEASE EDUCATIONAL CURRICULUM, TRAINING MODULES AND WEBSITE TO FOSTER INCREASED ADOLESCENT AUTONOMY AND MEDICAL LITERACY.STRATEGY 4. RECRUIT FOR NEW SICKLE CELL FELLOWSHIP.ACTIONS TAKEN: - TRANSITION NAVIGATOR WAS HIRED BY METHODIST AND WORKS PART-TIME AT ST. JUDE ADOLESCENT SICKLE CELL DISEASE (SCD) CLINIC TO SUPPORT EMERGING ADULTS IN ENGAGING IN THEIR FIRST AND SUBSEQUENT VISITS. - 47 PATIENTS WITH SCD WERE TRANSFERRED CARE FROM ST. JUDE TO ADULT CLINICS, COMPRISING A RATE OF ADULT CARE PLACEMENT OF 94% FOR THE PAST YEAR. - 8 PATIENTS ATTENDED THE TRANSITION TOUR THIS PAST YEAR. - 139 PATIENTS RECEIVED TRANSITION EDUCATION THIS PAST YEAR. - TWO ADULT HEMATOLOGISTS NOW ATTEND THE ADOLESCENT CLINIC AT ST. JUDE.HEALTH NEED IDENTIFIED: TRANSITION OF PATIENTS FROM PEDIATRIC TO ADULT HEALTHCARE - CANCER SURVIVORSSTRATEGY 1. PROVIDE WORKSHOPS AND SPEAKERS THAT OFFER INFORMATION ABOUT AVAILABLE RESOURCES.STRATEGY 2. GIVE SURVIVORS AND THEIR FAMILIES THE OPPORTUNITY TO LEARN FROM OTHER SURVIVORS.STRATEGY 3. ENSURE THAT SURVIVORS UNDERSTAND HOW TO APPROACH HEALTHCARE POST-TREATMENT.STRATEGY 4. OFFER AN ONLINE RESOURCE FOR CONTINUOUS FLOW OF SURVIVORSHIP INFORMATION (TOGETHER).STRATEGY 5. ASSESS LATE EFFECTS OF CANCER THERAPY ON PEDIATRIC CANCER SURVIVORS.STRATEGY 6. USE INFORMATION FROM THESE STUDIES TO DEFINE RISK GROUPS FOR VARIOUS LATE EFFECTS AND ASSESS INTERVENTION.

ACTIONS TAKEN:
"- SURVIVORSHIP CLINICAL ACTIVITIES HAVE FOCUSED ON EDUCATING SURVIVORS ABOUT POTENTIAL HEALTH RISKS AND RISK MITIGATION MEASURES AND FACILITATING THEIR ACCESS TO SURVEILLANCE AND REMEDIAL INTERVENTION. SURVIVORS AND FAMILIES ARE COUNSELED TO ENROLL IN THE PATIENT PORTAL AND OR APP TO ENSURE THEY HAVE OPTIMAL ACCESS TO CLINICAL DATA TO SHARE WITH LOCAL HEALTH CARE PROVIDERS AND THAT THE INSTITUTION HAS ACCURATE CONTACT INFORMATION. - THE SURVIVORSHIP TEAM HAS PARTICIPATED IN A VARIETY OF ONLINE/VIRTUAL FORUMS TO EDUCATE SURVIVORS/FAMILIES, GRADUATE MEDICAL TRAINEES, AND BEHAVIORAL AND MEDICAL HEALTH CARE PROVIDERS ABOUT SURVIVORSHIP CARE. EXAMPLES OF LECTURES/SEMINARS FOLLOW: -- DR. MELISSA M. HUDSON: SCIENCE OF CHILDHOOD CANCER VIRTUAL LECTURE SERIES, ""THE ROLE OF SURVIVORSHIP RESEARCH IN ADVANCING CHILDHOOD CANCER CARE AND QUALITY OF SURVIVAL"", SEPTEMBER 2, 2021. -- DR. MATTHEW EHRHARDT: SURVIVORSHIP CARE PLANNING. VIVA FOUNDATION FOR CHILDREN WITH CANCER ANNUAL CONFERENCE, VIRTUAL (SINGAPORE), JANUARY 2022. -- DR. STEPHANIE DIXON: DIXON SB. OPTIMAL MANAGEMENT AND TREATMENT COORDINATION OF LONG-TERM TOXICITIES IN PEDIATRIC LEUKEMIA. GLOBAL LEUKEMIA ACADEMY LATIN AMERICA 2022: EMERGING AND PRACTICAL CONCEPTS AND CONTROVERSIES IN LEUKEMIAS. MARCH 2022. -- DR. DANIEL MULROONEY: ORGAN HEALTH AFTER CHILDHOOD CANCER - CARDIAC LATE EFFECTS, ST. JUDE CHILDREN'S RESEARCH HOSPITAL-VIVA SURVIVORSHIP, JANUARY 2022.HEALTH NEED IDENTIFIED: OUTPATIENT CARE EXPERIENCE - TRANSITION OF CARE FROM SPECIALTY TO PRIMARY CARE PROVIDERSSTRATEGY 1. DEVELOP MATERIALS TO EDUCATE PATIENTS ON THE PROCESS OF FINDING A PRIMARY CARE PROVIDER IN THEIR COMMUNITY WHO ACCEPTS THEIR HEALTH INSURANCE.STRATEGY 2. WORK WITH HIMS/CLINICAL INFORMATICS TO REVIEW STATISTICS/REPORTS RE: ""FAMILY PHYSICIAN"" FIELD IN EMR.STRATEGY 3. DEVELOP PROCESS FOR CAPTURING OUTCOMES RELATED TO PRIMARY CARE PROVIDER IDENTIFICATION.STRATEGY 4. INCREASE THE PERCENTAGE OF ONCOLOGY TREATMENT SUMMARIES SENT TO PRIMARY CARE PROVIDERS WITHIN TWO WEEKS OF THERAPY COMPLETION. ACTIONS TAKEN: - PROVIDE EDUCATIONAL MATERIALS TO PATIENTS WHO NEED HEALTH CARE PROVIDERS IN THEIR LOCAL COMMUNITIES. - DEVELOPED A NEW HANDOUT IDENTIFYING LOCAL MENTAL HEALTH PROVIDERS. - IMPLEMENTED NEW EPIC REPORT TO TRACK STATISTICS. - CREATED ""TRANSITION"" TAB IN EPIC WHERE IS READILY VIEWABLE BY PATIENT'S CARE TEAM. - CREATED A WORKING GROUP WHO ARE TASKED WITH DESIGNING AN EVIDENCE-BASED CLINICAL PATHWAY TO GUIDE THE TRANSITION FROM ST. JUDE SUB-SPECIALISTS TO SUB-SPECIALISTS IN THE PATIENT'S LOCAL COMMUNITY. - ADDED AN ""ESTIMATED DATE OF THERAPY COMPLETION"" FIELD IN EPIC TO FACILITATE TIMELY TRANSITION PLANNING AND COMMUNICATION BETWEEN CARE TEAMS. HEALTH NEED IDENTIFIED: OUTPATIENT CARE EXPERIENCE - PHYSICIAN COORDINATION OF CARE STRATEGY 1. CONTINUE TO IMPROVE THE CLINICIAN PORTAL TO PERMIT REFERRING AND AFFILIATED PHYSICIANS' CONVENIENT ACCESS TO PATIENT INFORMATION, IN ACCORDANCE WITH APPLICABLE LAW.ACTIONS TAKEN: - AFFILIATE PROGRAM COMPLETED A QUALITY IMPROVEMENT PROJECT TO IMPROVE COMMUNICATION AND TRANSITION FLOW FOR SHARED AFFILIATE PATIENTS ON NON-PROTOCOL TREATMENT PLANS. - COMPLETED ANNUAL COMMUNICATION SURVEY WHICH HELPS TO GUIDE NEW COORDINATION OF CARE INITIATIVES. - EXPANDED THE AFFILIATE NAVIGATOR PROGRAM TO INCLUDE CARE COORDINATION. - INTRODUCED CARE EVERYWHERE AND EPIC CARE LINK PROCESSES TO FACILITATE REFERRALS, CLINICIAN ACCESS TO PATIENT INFORMATION AND TRANSITION OF CARE ACTIVITIES. AIM #3 IMPROVING CHILD HEALTH STATUSHEALTH NEED IDENTIFIED: COMMUNITY HEALTH EDUCATIONSTRATEGY 1. ST. JUDE PROFESSIONALS WILL PROVIDE INFORMATION AND RESOURCES ABOUT SICKLE CELL DISEASE, HIV, CANCER, FLU, AND OTHER PEDIATRIC LIFE-THREATENING DISEASES.STRATEGY 2. OFFER EDUCATIONAL OPPORTUNITIES AND OTHER INFORMATION ABOUT HEALTHCARE CAREERS.ACTIONS TAKEN: - TOGETHER BY ST. JUDE WEBSITE PROVIDES RELIABLE MEDICAL EXPLANATIONS AND CLINICAL CARE INFORMATION IN EASY-TO-UNDERSTAND LANGUAGE. IT IS AVAILABLE TO PATIENTS AND THEIR FAMILIES ANYWHERE IN THE WORLD WITH CONTENT IS NOW AVAILABLE IN 10 LANGUAGES: ENGLISH, ARABIC, BURMESE, CHINESE (SIMPLIFIED), FRENCH, HINDI, PORTUGUESE, RUSSIAN, SPANISH AND URDU. - VACCINES BRING US CLOSER CAMPAIGN ILLUSTRATES THE IMPORTANCE OF THE COVID-19 VACCINE AND ITS ROLE IN HELPING TO END THE PANDEMIC. THE CAMPAIGN BEGAN AS AN INTERNAL INITIATIVE FOCUSED ON EMPLOYEE VACCINATION TO KEEP PATIENTS AND THEIR FAMILIES SAFE FROM COVID-19, BUT EXPANDED TO EXTERNAL AUDIENCES THROUGH STORIES, VIDEOS AND GRAPHICS FEATURED ON THE ST. JUDE WEBSITE AND SOCIAL MEDIA PLATFORMS. - PROGRESS BLOG POSTS: ST. JUDE PUBLISHED 40BLOG POSTS THIS YEAR WITH EDUCATIONAL INFORMATION ONBASIC RESEARCH, COVID-19, HPV, SAFER UKRAINE, AND GENERAL CHILDHOOD CANCER AND HEALTH RESOURCES. - COMMUNITY EDUCATION AND ENGAGEMENT: IN FY22, ST. JUDE OPENED THE DOOR TO HEALTH CARE CAREER POSSIBILITIES FOR MORE THAN 1,400 LOCAL EIGHTH GRADERS DURING THE JUNIOR ACHIEVEMENT OF MEMPHIS AND THE MID-SOUTH'S INSPIRE EXPO. THE INTERACTIVE BOOTH BROUGHT PATIENT AND RESEARCH SETTINGS TO LIFE FOR STUDENTS WITH ACTIVITIES SUCH AS TAKING A BLOOD PRESSURE, PERFORMING CHEST COMPRESSIONS, LOOKING UNDER A MICROSCOPE AND ENGAGING WITH RESEARCHERS AND CLINICAL STAFF.HEALTH NEED IDENTIFIED: PREVENTING VIRUS-ASSOCIATED CANCERS THROUGH INCREASED HPV VACCINATIONSTRATEGY 1. LAUNCH SEARCH COMMITTEE, DEVELOP AND EVALUATE CANDIDATES, HIRE AND ONBOARD A NEW FACULTY DIRECTOR FOR THE HPV CANCER PREVENTION INITIATIVE.STRATEGY 2. CONTINUE AND/OR STRENGTHEN PARTNERSHIPS WITH OTHERS IN THE HPV VACCINATION SPACE (E.G. NATIONAL HPV VACCINATION ROUNDTABLE, HPV CANCER FREE TENNESSEE) THROUGH ACTIVE PARTICIPATION IN COMMITTEES AND MEETINGS."

ACTIONS TAKEN:
"- LAUNCHED AND IMPLEMENTED A PUBLIC AWARENESS CAMPAIGN PROMOTING ON-TIME HPV VACCINATION WITH MORE THAN 110 ORGANIZATIONAL AND INDIVIDUAL CAMPAIGN PARTNERS (PATH TO A BRIGHT FUTURE). - ESTABLISHED AND SUPPORTED THE MEMPHIS AND SHELBY COUNTY HPV CANCER PREVENTION ROUNDTABLE. - DEVELOPED STATE HPV DATA PROFILES FOR TENNESSEE, ARKANSAS, MISSOURI, MISSISSIPPI, ALABAMA, AND LOUISIANA THAT INCLUDE THE MOST CURRENT HPV DATA AND TRENDS TO INFORM ACTIONABLE OPPORTUNITIES TO INCREASE HPV VACCINATION COVERAGE. - HOSTED FIVE VIRTUAL SEMINARS IN SUPPORT OF INTERNATIONAL HPV AWARENESS DAY. THE SEMINARS HAD A TOTAL OF 785 ATTENDEES. - ADDITIONALLY, THE PROGRAM TEAM MEMBERS PARTICIPATED IN MULTIPLE MEETINGS WITH PARTNERS, INCLUDING NATIONAL HPV VACCINATION ROUNDTABLE, CDC, AMERICAN CANCER SOCIETY, HPV CANCER FREE TENNESSEE COALITION, PREVENT CANCER FOUNDATION, MERCK, GLOBAL INITIATIVE AGAINST HPV AND CERVICAL CANCER. PARTNERSHIP OUTCOMES INCLUDED THE CONVENING OF A LOCAL HPV CANCER PREVENTION ROUNDTABLE FOR MEMPHIS AND SHELBY COUNTY, AS WELL AS ENGAGEMENT WITH PARTNERS IN ALABAMA, ARKANSAS, LOUISIANA, MISSISSIPPI, MISSOURI, AND TENNESSEE BY PARTICIPATING IN STATE-LEVEL COALITIONS AND WITH ORGANIZATIONS ADDRESSING HPV CANCER PREVENTION IN THESE STATES. HEALTH NEED IDENTIFIED: HIV COLLABORATION WITH COMMUNITY COALITIONSTRATEGY 1. FORGE ACTION-ORIENTED PARTNERSHIPS BETWEEN HEALTH RESEARCHERS AND COMMUNITY MEMBERS.STRATEGY 2. LINK YOUTH TO CONFIDENTIAL HIV TESTING, COUNSELING SERVICES AND SPECIALIZED YOUTH CARE.STRATEGY 3. STRENGTHEN SERVICES THAT SUPPORT YOUNG PEOPLE WITH HIV AND RELATED MEDICAL AND SOCIAL PROBLEMS. STRATEGY 4. FOCUS PREVENTION STRATEGIES WHERE SOCIAL DETERMINANTS OF HEALTH EXISTS, AND HELP IS MOST NEEDED.ACTIONS TAKEN: - THE OUTREACH TEAM HOSTED 11 VIRTUAL CONNECT TO PROTECT (C2P) MEMPHIS COMMUNITY COALITION MEETINGS, AVERAGING 33 ATTENDEES. C2P MEMPHIS IS A COALITION OF 25 PLUS COMMUNITY-BASED STAKEHOLDERS WITH A SHARED VISION OF OPTIMIZING HIV PREVENTION AND TREATMENT IN SHELBY COUNTY. THESE VIRTUAL MEETINGS PROVIDED A FORUM FOR OUTSIDE COLLABORATORS (""SPARK"" PROJECT [UNIVERSITY OF CONNECTICUT] AND SHIFT PROJECT [MEHARRY MEDICAL COLLEGE]) TO SHARE ABOUT RESEARCH PROJECTS. THE VIRTUAL MEETINGS HIGHLIGHTED THE WORK OF C2P MEMBER AGENCIES INCLUDING THOSE THAT HAVE RECEIVED CDC FUNDS AS PART OF ENDING THE HIV EPIDEMIC (EHE) FUNDING. - THE OUTREACH TEAM WITH THE C2P COALITION ALSO HOSTED A MEETING WITH THE LEADERSHIP OF THE FAST-TRACK CITIES INITIATIVE. THE FAST-TRACK CITIES INITIATIVE, WITH THE CORE PARTNERS OF UNAIDS, THE CITY OF PARIS, THE INTERNATIONAL ASSOCIATION OF PROVIDERS OF AIDS CARE (IAPAC) AND UN-HABITAT, SERVES TO PROVIDE SUPPORT TO PRIORITY CITIES TO ""FAST-TRACK"" THEIR HIV RESPONSES, TO DELIVER ON THE COMMITMENTS OF THE PARIS DECLARATION TO END THE AIDS EPIDEMIC BY 2030, AND TO ADDRESS DISPARITIES IN ACCESS TO BASIC HEALTH AND SOCIAL SERVICES, SOCIAL JUSTICE, AND ECONOMIC OPPORTUNITIES. - THE OUTREACH TEAM MAINTAINS A STRONG LINKAGE TO CARE PROGRAM IN COLLABORATION WITH THE LOCAL SHELBY COUNTY HEALTH DEPARTMENT AND COMMUNITY PARTNERS. OF THE APPROXIMATE 62 NEWLY DIAGNOSED YOUTH REFERRALS RECEIVED, 49 (UNDER 24 YEARS OF AGE), WERE LINKED TO CARE. - THE OUTREACH TEAM PARTICIPATED IN 24 OUTREACH EVENTS REACHING A TOTAL OF 1,292 INDIVIDUALS, WITH A FOCUS ON YOUTH. ENGAGEMENT AT THESE EVENTS INCLUDES DISSEMINATION OF INFORMATION ABOUT HIV PREVENTION CLINICAL TRIALS. IN FY22 THERE WERE TWO LONG-ACTING ANTIRETROVIRAL PREVENTION TRIALS THAT THE TEAM SHARED INFORMATION ABOUT IN THE COMMUNITY. - THE OUTREACH TEAM CLOSELY COLLABORATED WITH THE TENNESSEE DEPARTMENT OF HEALTH, AND WITH CDC FUNDING, ACTED AS THE ENDING THE HIV EPIDEMIC COORDINATING CENTER FOR SHELBY COUNTY. THE TEAM HELPED MAINTAIN THE HTTPS://ENDHIV901.ORG/ WEBPAGE THAT SERVES AS THE DASHBOARD FOR ALL EHE-RELATED RESOURCES IN THE COUNTY AND HELPED WITH THE SELECTION, SETUP, AND HOSTING OF THE ENDHIV901 COMMUNITY ADVISORY BOARD.HEALTH NEED IDENTIFIED: CHILD KNOWLEDGE OF CANCER PREVENTION, NUTRITION, OBESITY, AND PHYSICAL ACTIVITY STRATEGY 1. PARTNER WITH LOCAL EDUCATION AGENCIES TO DISSEMINATE CANCER AND HEALTHY LIVING EDUCATIONAL PROGRAMS.ACTIONS TAKEN: - IMPLEMENTED THE KINDERGARTEN COLLABORATIVE, A PARTNERSHIP WITH MEMPHIS SHELBY COUNTY SCHOOLS TO CO-CREATE LEARNING MODULES THAT INTEGRATE SCIENCE EDUCATION WITH LITERACY, NUMERACY, AND SOCIAL AND EMOTIONAL SKILL DEVELOPMENT. YOUNG LEARNERS EXPLORE HOW INFECTIOUS DISEASES ARE SPREAD FROM PERSON TO PERSON AND DEVELOP AN INTERVENTION THAT CAN PREVENT THE SPREAD OF DISEASE IN THEIR CLASSROOM. THE PROGRAM WAS FACILITATED AT 5 ELEMENTARY SCHOOLS WITH 12 KINDERGARTEN TEACHERS TO OVER 240 KINDERGARTEN STUDENTS. - THE AFTERSCHOOL STEM CLUBS TEACH 5TH GRADE STUDENTS ABOUT THE SIGNS AND SYMPTOMS OF OSTEOSARCOMA, POSITIONING THEM AS PHYSICIAN SCIENTISTS AND ENGINEERS TO DIAGNOSE AND TREAT THE DISEASE. THE CLUB WAS DELIVERED AT 21 ELEMENTARY SCHOOLS AND REACHED 250 5TH GRADE STUDENTS IN MEMPHIS SHELBY COUNTY SCHOOLS. - MIDDLE SCHOOL COMMUNITY HEALTH CLUBS FACILITATE MIDDLE SCHOOL STUDENTS' (GRADES 6-8) EXPLORATION OF CANCER METRICS AND SOCIAL DETERMINANTS OF HEALTH. YOUTH PARTICIPATING IN THE CLUB DEVELOP AN INFOGRAPHIC TO INCREASE AWARENESS OF UPSTREAM FACTORS THAT CREATE ENVIRONMENTS WHERE CANCER DISPARITIES CAN EXIST. THE CLUB WAS OFFERED AT 2 MIDDLE SCHOOLS AND REACHED 30 MIDDLE SCHOOL STUDENTS. - THE CANCER CONTROL AND DISPARITIES FELLOWSHIP IS A RESEARCH IMMERSION PROGRAM THAT IS COUPLED WITH A TEACHER-LED CLASSROOM LEARNING MODULE DELIVERED DURING THE ACADEMIC YEAR. AS PART OF THEIR CLASSROOM LEARNING, YOUTH EXPLORE CANCER METRICS USING DATA ON THE NCI STATE PROFILES WEBSITE TO IDENTIFY CANCER DISPARITIES IN THEIR COMMUNITY. THEN, USING THE SOCIAL DETERMINANTS OF HEALTH FRAMEWORK, THEY PROPOSE A CANCER CONTROL PROGRAM THAT ADDRESSES UPSTREAM FACTORS THAT CREATE ENVIRONMENTS WHERE THESE DISPARITIES CAN EXIST. STUDENTS WHO PARTICIPATE IN THE CURRICULUM ARE ELIGIBLE TO APPLY FOR A RESEARCH IMMERSION PROGRAM WHERE THEY WORK WITH A PUBLIC HEALTH EXPERT TO RESEARCH CANCER CONTROL PROGRAMS DURING THE SUMMER. THE FELLOWSHIP CURRICULUM WAS DELIVERED IN 2 SCHOOLS IN THE MEMPHIS AREA TO APPROXIMATELY 240 HIGH SCHOOL STUDENTS. - THE CANCER EDUCATION AND OUTREACH PROGRAM PARTNERED WITH THE MEMPHIS SHELBY COUNTY SCHOOLS SUMMER LEARNING ACADEMY TO OFFER CANCER AND HEALTH EDUCATION TO APPROXIMATELY 150 YOUTH."

ST. JUDE CHILDREN'S RESEARCH HOSPITAL:
PART V, SECTION B, LINE 7A: THE CHNA REPORT WAS MADE WIDELY AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/ABOUT-ST-JUDE/FINANCIALS/COMMUNITY-HEALTH-NEEDS- ASSESSMENT.HTMLST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 10A: THE HOSPTIAL FACILITY'S MOST RECENTLY ADOPTED IMPLEMENTATION STRATEGY IS AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/ABOUT-ST-JUDE/FINANCIALS/COMMUNITY-HEALTH-NEEDS- ASSESSMENT.HTMLST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 14: ST. JUDE CURRENTLY DOES NOT BILL NOR PURSUE PAYMENT FOR ANY ST. JUDE PATIENT; THEREFORE, ST. JUDE DOES NOT HAVE A BASIS FOR CALCULATING AMOUNTS CHARGED TO PATIENTS.ST. JUDE CHILDREN'S RESEARCH HOSPITAL: PART V, SECTION B, LINE 16A: THE FAP WAS MADE WIDELY AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTMLST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 16B: BASED ON THE FINANCIAL ASSISTANCE STATEMENT (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL- ASSISTANCE-STATEMENT.HTML) AND FINANCIAL ASSISTANCE POLICY (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTML), ST. JUDE DOES NOT HAVE AN APPLICATION FORM.ST. JUDE CHILDREN'S RESEARCH HOSPITAL:PART V, SECTION B, LINE 16C: A PLAIN LANGUAGE SUMMARY WAS MADE WIDELY AVAILABLE AT THE FOLLOWING URL: HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-STATEMENT.HTML

PART I, LINE 3C:
NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. ALL PATIENTS ARE ELIGIBLE TO RECEIVE MEDICAL CARE AND SUPPORT SERVICES AT NO COST. THERE ARE NO TESTS OR THRESHOLDS APPLIED TO DETERMINE ELIGIBILITY FOR FINANCIAL ASSISTANCE. ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE REGARDLESS OF THEIR ABILITY TO PAY.

PART I, LINE 7:
COST-TO-CHARGE RATIO DERIVED FROM WORKSHEET 2, RATIO OF PATIENT CARE COST TO CHARGES. COST-TO-CHARGE RATIO USED FOR LINE 7A FINANCIAL ASSISTANCE AT COST, LINE 7B MEDICAID, AND LINE 7C COSTS OF OTHER MEANS-TESTED GOVERNMENT PROGRAMS.

PART I, LINE 7G:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL INCLUDED AS SUBSIDIZED HEALTH SERVICES SUPPORT FOR EIGHT AFFILIATE CLINICS TOTALING APPROXIMATELY $7.9 MILLION.

PART II, COMMUNITY BUILDING ACTIVITIES:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS AN ACTIVE AND ENGAGED MEMBER OF THE MEMPHIS HEALTH COMMUNITY. EMPLOYEES PARTICIPATE IN BUSINESS, EDUCATION, OUTREACH AND CIVIC PROGRAMS AND ACTIVITIES FOSTERING ECONOMIC DEVELOPMENT AND COMMUNITY HEALTH IMPROVEMENT ADVOCACY WHICH PROMOTE THE HEALTH AND WELLNESS OF THE COMMUNITIES WE SERVE.THE ST. JUDE CHILDREN'S RESEARCH HOSPITAL PRESIDENT AND CEO IS A MEMBER OF MEMPHIS TOMORROW. MEMPHIS TOMORROW IS AN ASSOCIATION OF CHIEF EXECUTIVE OFFICERS OF MEMPHIS' LARGEST ENTERPRISES. THE PURPOSE IS TO BRING TOP BUSINESS LEADERS TOGETHER WITH GOVERNMENT AND CIVIC LEADERS TO FOSTER ECONOMIC PROSPERITY FOR ALL WHO LIVE IN OUR COMMUNITY. THEIR INITIATIVES ARE FOCUSED IN THOSE AREAS WHICH DIRECTLY IMPACT ECONOMIC GROWTH AND OPPORTUNITY, INCLUDING HUMAN CAPITAL DEVELOPMENT, INDUSTRY DEVELOPMENT, AND PUBLIC SAFETY. ST. JUDE ALSO PARTICIPATES WITH MEMPHIS FAST FORWARD WHOSE STRATEGIES ARE BASED ON THE PREMISE THAT ECONOMIC GROWTH AND PROSPERITY, AND IMPROVED QUALITY OF LIFE, WILL FOLLOW ONCE MEMPHIS AND SHELBY COUNTY SUCCESSFULLY ADDRESS THE BASICS: GOOD JOBS, QUALITY EDUCATION, SAFE STREETS AND EFFICIENT GOVERNMENT. ST. JUDE IS A MEMBER OF THE ASPIRING FOR PURCHASING EXCELLENCE (APEX) ASSOCIATION OF MEMPHIS. APEX IS AN ASSOCIATION OF PURCHASING AND PROCUREMENT PROFESSIONALS FROM MEMPHIS ORGANIZATIONS WHOSE PURPOSE IS TO PROMOTE BEST PRACTICES IN SUPPLIER DIVERSITY. ADDITIONALLY, ST. JUDE IS GOLD SPONSOR FOR THE MID-SOUTH MINORITY BUSINESS COUNCIL (MMBC) ECONOMIC DEVELOPMENT FAIR. THE MMBC SERVES AS THE MID-SOUTH'S FOREMOST MINORITY BUSINESS DEVELOPMENT ORGANIZATION. THE MMBC HELPS TO DEVELOP A STRONG MINORITY AND WOMEN BUSINESS COMMUNITY TO IMPACT ECONOMICALLY THE ENTIRE MID-SOUTH REGION. THE PEDIATRIC ONCOLOGY EDUCATION (POE) PROGRAM BROUGHT IN 33 SUMMER STUDENTS FOR INTERNSHIPS IN BASIC SCIENCE OR CLINICAL RESEARCH. THE RHODES COLLEGE SUMMER PLUS PROGRAM ACCEPTS 15 STUDENTS INTO THE HOSPITAL'S RESEARCH LABORATORIES FOR A PERIOD OF ONE SUMMER, ONE ACADEMIC YEAR, AND A SECOND SUMMER. IN 2022, ST. JUDE HOSTED 16 SHELBY COUNTY HIGH SCHOOL STUDENTS FOR AN IMMERSIVE SUMMER LAB INTERNSHIP PROGRAM. THESE PROGRAMS SUPPORT INCREASING THE AWARENESS OF CAREERS IN RESEARCH SCIENCE, HEALTHCARE, OR HEALTHCARE MANAGEMENT AND CONTRIBUTE TO PREPARING STUDENTS TO ENTER THESE CAREERS. THE CLINICAL EDUCATION AND TRAINING OFFICE HOSTS APPROXIMATELY 50 STUDENTS ANNUALLY FOR PATIENT CARE SHADOWING AND ROTATION EXPERIENCES. THESE STUDENTS ARE AT DIFFERENT STAGES OF TRAINING AND ARE GENERALLY IN MEDICAL SCHOOL. THIS PROGRAM HELPS PARTICIPANTS DETERMINE THEIR CAREER IN MEDICINE ACROSS THE FIELDS OF ONCOLOGY, HEMATOLOGY AND INFECTIOUS DISEASES.THE FAMILY, GUEST AND VOLUNTEER SERVICES DEPARTMENT PROVIDES SUMMER PROGRAMS FOR HIGH SCHOOL STUDENTS AND YEAR-ROUND PROGRAMS FOR COLLEGE STUDENTS. BOTH PROGRAMS DRIVE ENTRY INTO HEALTH CAREERS. THE DEPARTMENT ALSO ENGAGES TWELVE FULL-TIME INTERNS, 4 EACH SEMESTER, WHO ARE EMBEDDED ON THE TEAM AND PREPARED FOR CAREERS IN NON-PROFIT LEADERSHIP OR HEALTHCARE MANAGEMENT. ST. JUDE OFFERS EXPERIENTIAL LEARNING INTERNSHIPS ACROSS MANY AREAS FROM SCIENCE TO LEGAL, INFORMATION SERVICES, HUMAN RESOURCES, COMMUNICATION AND ACCOUNTING. THE CHIEF GOVERNMENT AFFAIRS OFFICER SERVES ON THE BOARD OF DIRECTORS OF THE MEMPHIS RIVER PARKS PARTNERSHIP (MRPP). THE MRPP IS A NON-PROFIT ORGANIZATION THAT, UNDER A LONG-TERM CONTRACT WITH THE CITY OF MEMPHIS, MANAGES ALL THE PARKS ALONG A 5-MILE STRETCH OF THE MEMPHIS RIVERFRONT. ELEMENTS ALONG THE RIVER FOSTER HEALTHY LIFESTYLES INCLUDING RIVERFIT, A SERIES OF PHYSICAL FITNESS CHALLENGES, AND A PLAYGROUND DESIGNED SPECIFICALLY FOR CHILDREN AT BEALE ST. LANDING.THE CHIEF GOVERNMENT AFFAIRS OFFICER SERVES ON THE BOARD OF COMMISSIONERS OF THE MEMPHIS AREA TRANSIT AUTHORITY (MATA). HE HELPS TO PROMOTE THE HEALTH OF THE COMMUNITY BY ADVOCATING FOR POLICIES THAT ENABLE ENHANCED MOBILITY FOR A LARGER PERCENTAGE OF THE POPULATION OF MEMPHIS AND SHELBY COUNTY.THE CHIEF LEGAL OFFICER IS BOARD COUNSEL, AND A BOARD MEMBER OF THE MEMPHIS CHILD ADVOCACY CENTER, WHICH HELPS LOCAL CHILDREN FIND SAFETY AND HEALING (INCLUDING ACCESS TO A MENTAL HEALTH PROFESSIONAL) AFTER A REPORT OF SEXUAL OR OTHER SEVERE ABUSE AND OFFERS ABUSE PREVENTION TRAINING TO COMMUNITY VOLUNTEERS AND PARENTS. THE MANAGING COUNSEL FOR HEALTH AFFAIRS SERVES ON THE BOARD OF THE MEMPHIS BAR ASSOCIATION HEALTH LAW SECTION.

PART III, LINE 2:
BAD DEBT EXPENSE IS EQUAL TO CHARGES ON ACCOUNTS DETERMINED TO BEUNCOLLECTIBLE.THERE WERE NO UNCOLLECTIBLE ACCOUNTS IN THE CURRENT YEAR.

PART III, LINE 3:
ALL PATIENTS ARE ELIGIBLE FOR FINANCIAL ASSISTANCE UNDER THE FINANCIAL ASSISTANCE POLICY. THERE WAS NO BAD DEBT EXPENSE ATTRIBUTABLE TO PATIENTS UNDER THE FINANCIAL ASSISTANCE POLICY. ST. JUDE CHILDREN'S RESEARCH HOSPITAL DOES NOT CONSIDER BAD DEBT EXPENSE A COMMUNITY BENEFIT.

PART III, LINE 4:
NET PATIENT SERVICE REVENUES - NET OPERATING REVENUES ARE RECORDED AT THE TRANSACTION PRICE ESTIMATED BY THE HOSPITAL TO REFLECT THE TOTAL CONSIDERATION DUE FROM THIRD-PARTY PAYORS IN EXCHANGE FOR PROVIDING GOODS AND SERVICES IN PATIENT CARE. THESE SERVICES ARE CONSIDERED TO BE A SINGLE PERFORMANCE OBLIGATION AND HAVE A DURATION OF LESS THAN ONE YEAR. REVENUES ARE RECORDED AS THESE GOODS AND SERVICES ARE PROVIDED. THE TRANSACTION PRICE, WHICH INVOLVES SIGNIFICANT ESTIMATES, IS DETERMINED BASED ON THE HOSPITAL'S STANDARD CHARGES FOR THE GOODS AND SERVICES PROVIDED, WITH A REDUCTION RECORDED FOR PRICE CONCESSIONS RELATED TO THIRD PARTY CONTRACTUAL ARRANGEMENTS AS WELL AS OTHER IMPLICIT PRICE CONCESSIONS.

PART III, LINE 8:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL DOES NOT CONSIDER THE MEDICARE SHORTFALL A COMMUNITY BENEFIT. THE COST TO CHARGE RATIO WAS USED TO DETERMINE MEDICARE ALLOWABLE COSTS OF CARE.

PART III, LINE 9B:
ALL PATIENTS ACCEPTED FOR ST. JUDE TREATMENT RECEIVE CARE WHETHER OR NOT THEY OR THEIR FAMILIES CAN PAY FOR IT. ST. JUDE DOES HAVE A BILLING SYSTEM, BUT PATIENTS DO NOT RECEIVE BILLS. IF THE PATIENT HAS INSURANCE, ST. JUDE BILLS THE INSURANCE PLAN OR OTHER ORGANIZATION THAT PAYS HEALTH COSTS. THIS IS SET FORTH IN OUR FINANCIAL ASSISTANCE STATEMENT (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-STATEMENT.HTML) AND FINANCIAL ASSISTANCE POLICY (HTTPS://WWW.STJUDE.ORG/ LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTML).

PART VI, LINE 2:
CANCERPEDIATRIC CANCERS ARE RARE COMPARED TO ADULT CANCERS. ONLY 10,470 NEW CASES ARE EXPECTED TO OCCUR AMONG CHILDREN 14 YEARS OF AGE AND YOUNGER IN 2022; HOWEVER, CANCER IS THE LEADING CAUSE OF DISEASE-RELATED DEATH IN U.S. CHILDREN. THE PRINCIPAL FOCUS OF ST. JUDE CHILDREN'S RESEARCH HOSPITAL IS CANCER. SEVENTY-FIVE PERCENT OF ALL RESOURCES AT ST. JUDE ARE INVESTED IN ELUCIDATING BASIC BIOLOGICAL MECHANISMS OF PEDIATRIC CANCERS AND TRANSLATING THIS KNOWLEDGE INTO IMPROVED DIAGNOSTIC TOOLS AND CURATIVE THERAPIES, WHILE MINIMIZING LONG-TERM SIDE EFFECTS. AS THE FIRST AND ONLY NATIONAL CANCER INSTITUTE-DESIGNATED COMPREHENSIVE CANCER CENTER FOCUSED EXCLUSIVELY ON CHILDREN, ST. JUDE SERVES AS A NATIONAL RESOURCE FOR RESEARCH AND TREATMENT OF PEDIATRIC CANCERS. OUR INITIATIVES ARE DESIGNED TO IMPACT PEDIATRIC CANCER TREATMENT ON A LOCAL, REGIONAL, NATIONAL AND GLOBAL SCALE. THERE ARE NO KNOWN DIFFERENCES IN PEDIATRIC CANCER INCIDENCE BY GEOGRAPHIC REGION IN THE U.S. CONSEQUENTLY, IT IS NOT POSSIBLE TO CATER OUR CLINICAL TRIALS TO TARGET PEDIATRIC CANCERS SPECIFICALLY PREVALENT IN OUR CATCHMENT AREA. WHILE NUMEROUS ADULT CANCERS HAVE BEEN SHOWN TO HAVE HIGH VARIATION IN INCIDENCE RATES ACROSS RACES AND ETHNICITIES, THE SITUATION IS LESS CLEAR IN PEDIATRIC CANCER, WHERE FEWER DISCREPANCIES HAVE BEEN IDENTIFIED. ALTHOUGH OUR CATCHMENT AREA HAS A HIGHER PROPORTION OF AFRICAN-AMERICAN PATIENTS THAN THE GENERAL U.S. POPULATION, THERE ARE VERY FEW EXAMPLES OF PEDIATRIC CANCERS IN WHICH THE INCIDENCE IS HIGHER IN RACIAL AND/OR ETHNIC MINORITIES. CONSEQUENTLY OUR RESEARCH AND CLINICAL TRIALS ADDRESS THE MOST PRESSING PROBLEMS IN PEDIATRIC CANCER. ST. JUDE OFFERS THERAPEUTIC TRIALS FOR THE TOP PEDIATRIC CANCERS INCLUDING ACUTE LYMPHOBLASTIC LEUKEMIA, MEDULLOBLASTOMA, NEUROBLASTOMA, HODGKIN LYMPHOMA, RETINOBLASTOMA, RHABDOMYOSARCOMA AND OTHERS. MANY OF THESE TRIALS ARE INSTITUTIONALLY SPONSORED; HOWEVER, ST. JUDE ALSO PARTICIPATES IN SEVERAL CLINICAL TRIALS CONSORTIA PROVIDING OUR CANCER PATIENTS ACCESS TO A VARIETY OF THERAPEUTIC STUDIES. PEDIATRIC CANCER PATIENTS MAY EXPERIENCE TREATMENT-RELATED SIDE EFFECTS MANY YEARS AFTER DIAGNOSIS. THE CHILDHOOD CANCER SURVIVOR STUDY AND ST. JUDE LIFE ARE TWO STUDIES, ACTIVE AT ST. JUDE, ASSESSING LATE EFFECTS OF CANCER THERAPY ON PEDIATRIC CANCER SURVIVORS. INFORMATION FROM THESE STUDIES WILL BE USED TO DEFINE RISK GROUPS FOR VARIOUS LATE EFFECTS AND ASSESS INTERVENTIONS. COMMUNITY OUTREACH AND ENGAGEMENT (COE) AT THE ST. JUDE COMPREHENSIVE CANCER CENTER (SJCCC) PROMOTES A COORDINATED APPROACH TO ENSURING THAT CHILDREN WHO HAVE CANCER, CHILDREN WHO HAVE SURVIVED CANCER, AND HEALTHY CHILDREN ALL BENEFIT FROM CUTTING-EDGE SCIENCE, CLINICAL CARE, AND PREVENTION EFFORTS PROVIDED BY THE SJCCC. THESE COE ACTIVITIES SPAN LOCAL, NATIONAL, AND GLOBAL GEOGRAPHIC AREAS THROUGH THE COLLECTIVE IMPACT OF THE ST. JUDE HPV CANCER PREVENTION PROGRAM, CANCER EDUCATION AND OUTREACH PROGRAM IN SCHOOLS, TOGETHER WEBSITE AND COMMUNITY, ST. JUDE AFFILIATE NETWORK, AND THE ST. JUDE GLOBAL PEDIATRIC MEDICINE PROGRAM. IN THE SUMMER OF 2022, ST. JUDE LAUNCHED THE HIGH SCHOOL AND COLLEGE RESEARCH IMMERSION PROGRAM. THIS PROGRAM OFFERED MEMPHIS-AREA HIGH SCHOOL AND COLLEGE STUDENTS AN OPPORTUNITY TO PARTICIPATE IN MENTORED RESEARCH PROJECTS IN ST. JUDE LABORATORY, PSYCHOLOGY, EPIDEMIOLOGY, CLINICAL OR DATA SCIENCE RESEARCH PROGRAMS. A PRIMARY GOAL OF THE PROGRAM WAS TO PROVIDE ACCESS AND OPPORTUNITIES TO PARTICIPATE IN MENTORED RESEARCH EXPERIENCE. THE ST. JUDE PATIENT FAMILY ADVISORY COUNCIL (PFAC) PROVIDES THE OPPORTUNITY FOR COE TO ENGAGE PATIENTS AND FAMILIES. A MEMBER OF THE COE LEADERSHIP TEAM IS ACTIVE IN THE PFAC AS A STAFF CHAMPION, ATTENDS MONTHLY MEETINGS, AND FACILITATES CONNECTIONS, AND SUPPORTS COMMUNICATION BETWEEN THE PFAC AND THE COE. THE HEALTHY CHILDREN ADVISORY COUNCIL WAS ALSO LAUNCHED IN 2021 TO MEANINGFULLY ENGAGE REPRESENTATIVES OF COMMUNITIES SERVED BY THE COMPREHENSIVE CANCER CENTER TO FUNCTION IN AN ADVISORY CAPACITY, SUCH AS BY PROVIDING ADVICE ON IDENTIFYING, PRIORITIZING, AND COMMUNICATING NEEDS ACROSS THE SJCCC AND TO COMMUNITIES. HEMATOLOGYMORE THAN 100,000 PEOPLE IN THE UNITED STATES HAVE SICKLE CELL DISEASE (SCD), AND IT IS ESTIMATED THAT MORE THAN 1 MILLION PEOPLE WORLDWIDE SUFFER FROM THE DISEASE. IT IS THE MOST FREQUENT GENETIC BLOOD DISORDER IN THE WORLD. ST. JUDE HAS ONE OF THE LARGEST PEDIATRIC SCD PROGRAMS IN THE COUNTRY AND PROVIDES COMPREHENSIVE TREATMENT AND EDUCATION TO ABOUT 900 CHILDREN WITH SCD IN THE GEOGRAPHIC CATCHMENT AREA. SCD IS DIAGNOSED BY STATE-WIDE NEWBORN SCREENING IN ALL 50 STATES. ST. JUDE HAS A PARTNERSHIP WITH NEWBORN SCREENING PROGRAMS IN TN AND MS THAT ENSURES A STABLE RELATIONSHIP AMONG PARENTS, PATIENTS, PRIMARY CARE PROVIDERS. ABOUT 50 NEWBORNS WITH SCD ARE IDENTIFIED EACH YEAR IN OUR GEOGRAPHIC CATCHMENT AREA. OUR SCD INFANT TODDLER PROGRAM CONTACTS AND ACCEPTS ALL CHILDREN DIAGNOSED WITH THE DISEASE IN OUR CATCHMENT AREA TO ITS COMPREHENSIVE CARE SERVICE. ADDITIONALLY, ST. JUDE PROVIDES TRAIT COUNSELING SERVICE TO INFANTS BORN WITH SICKLE CELL TRAIT TO 21 COUNTIES IN WESTERN TN. ST. JUDE PROVIDES CONFIRMATORY TESTING, EDUCATION AND COMPREHENSIVE CARE AND FOLLOW-UP THROUGHOUT CHILDHOOD FOR CHILDREN WITH SCD DISEASE. FROM BIRTH TO AGE 18 YEARS, PATIENTS ARE CLINICALLY EVALUATED AT LEAST EVERY 6 MONTHS, RECEIVE EDUCATION AND MULTI-DISCIPLINARY SERVICES ACCORDING TO STANDARDIZED TREATMENT AND EDUCATION GUIDELINES. SERVICES ALSO INCLUDE COMMUNITY OUTREACH AND EDUCATION OF THE LOCAL COMMUNITY. ST. JUDE HAS ESTABLISHED A FORMAL TRANSITION PROGRAM TO ADULT CARE FOR PATIENTS WITH SCD AND PROVIDES SUPPORT TO PATIENTS AND FAMILIES THROUGHOUT THE TRANSITION PROCESS BY WORKING CLOSELY WITH THE ADULT SCD PROGRAMS AT METHODIST UNIVERSITY HOSPITAL AND REGIONAL ONE HOSPITAL. ST. JUDE ALSO PROVIDES CLINICAL SERVICES FOR APPROXIMATELY 800 CHILDREN PER YEAR WITH OTHER NON-MALIGNANT HEMATOLOGICAL DISORDERS THROUGH A STRONG RELATIONSHIP WITH LOCAL COMMUNITY PHYSICIANS. CHILDREN FROM THE GEOGRAPHIC CATCHMENT AREA OF ST. JUDE WITH ILLNESSES SUCH AS HEMOPHILIA, APLASTIC ANEMIA, THROMBOSIS, THALASSEMIA, SPHEROCYTOSIS, AND IMMUNE THROMBOCYTOPENIC PURPURA AND OTHER NON-MALIGNANT HEMATOLOGIC DISORDERS ARE REFERRED TO AND RECEIVE STATE-OF THE-ART CARE FROM ST. JUDE PHYSICIANS AND MEDICAL STAFF. ST. JUDE IS ONE OF A SELECT GROUP OF FEDERALLY RECOGNIZED PEDIATRIC HEMOPHILIA TREATMENT CENTERS AND PROVIDES STATE-OF-THE-ART COMPREHENSIVE CARE TO APPROXIMATELY 300 CHILDREN WITH BLEEDING AND THROMBOSIS DISORDERS.IN ADDITION TO PROVIDING AND CONTINUOUSLY IMPROVING STANDARDIZED CARE TO THESE PATIENT POPULATIONS, ST. JUDE HEMATOLOGY DEDICATES SIGNIFICANT RESOURCES TO CLINICAL, TRANSLATIONAL, AND BASIC RESEARCH TO IMPROVE SURVIVAL AND DECREASE MORBIDITY OF CHILDREN WITH NON-MALIGNANT CHRONIC BLOOD DISEASES. MOST PATIENTS PARTICIPATE IN RESEARCH STUDIES, WHICH HAVE RESULTED IN MAJOR IMPROVEMENTS IN CLINICAL CARE. ST. JUDE IS PARTNERING WITH SEVERAL PHARMACEUTICAL AND BIOTECHNOLOGY COMPANIES TO PROVIDE ACCESS TO FIRST-IN-HUMAN GENETIC THERAPIES FOR SCD. ST. JUDE IS ALSO DEVELOPING SEVERAL NOVEL GENETIC THERAPIES TO CURE SCD. IN ADDITION, AN ONGOING CLINICAL TRIAL IS EVALUATING A NEW METHOD OF BONE MARROW TRANSPLANTATION FOR PATIENTS WITH SICKLE CELL DISEASE.(NOTE: THIS NARRATIVE FOR PART VI, LINE 2 IS CONTINUED BELOW) - SEE PAGE 86/115

PART VI, LINE 3:
"NO FAMILY EVER PAYS ST. JUDE FOR TREATMENT. IN ADDITION, ST. JUDE PROVIDES AN UNPARALLELED LEVEL OF SUPPORT SERVICES AT NO COST TO FAMILIES. WE ALSO HAVE PROGRAMS TO ASSIST FAMILIES IN ENROLLING IN VARIOUS PUBLIC ASSISTANCE PROGRAMS FOR WHICH THEY MAY QUALIFY, INCLUDING BUT NOT LIMITED TO TENNCARE/MEDICAID, COVERKIDS, CHIPS AND SOCIAL SECURITY. FAMILIES ALSO HAVE ACCESS TO AN ONLINE EDUCATIONAL RESOURCE TITLED ""YOU AND THE AFFORDABLE CARE ACT"" (HTTPS://WWW.STJUDE.ORG/TREATMENT/PATIENT-RESOURCES/ CAREGIVER-RESOURCES/PATIENT-FAMILY-EDUCATION-SHEETS/LEGAL-FINANCIAL/YOU-AND-THE-AFFORDABLE-CARE-ACT.HTML). THIS ENSURES AN APPROPRIATE SAFETY NET SHOULD THE FAMILY SEEK TREATMENT OUTSIDE OF ST. JUDE AND IT ALLOWS US TO BE GOOD STEWARDS OF DONOR DOLLARS. WE UTILIZE AN OUTSIDE CONTRACTOR TO PROVIDE APPLICATION ASSISTANCE. THE HOSPITAL'S FINANCIAL ASSISTANCE STATEMENT (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-STATEMENT.HTML) AND FINANCIAL ASSISTANCE POLICY (HTTPS://WWW.STJUDE.ORG/LEGAL/FINANCIAL-ASSISTANCE-POLICY.HTML) ARE POSTED ON THE HOSPITAL'S WEBSITE AND AVAILABLE AT REGISTRATION. THE DOCUMENTS ARE AVAILABLE IN ENGLISH AND SPANISH. FOR FAMILIES SPEAKING OTHER LANGUAGES, WE UTILIZE ONSITE INTERPRETER SERVICES AND/OR PROFESSIONAL CONTRACTED INTERPRETATION AND TRANSLATION SERVICES."

PART VI, LINE 4:
THE COMMUNITY SERVED BY ST. JUDE CAN BEST BE DEFINED BY THE ST. JUDE PATIENT POPULATION AND SCOPE OF CLINICAL SERVICES. ST. JUDE SERVES AS A NATIONAL REFERRAL CENTER FOR CHILDREN WITH CATASTROPHIC DISEASES, SUCH AS CANCER, AS WELL AS A LOCAL REFERRAL CENTER FOR CHILDREN WITH CANCER, BLOOD DISORDERS, HIV/AIDS, AND NEUROLOGICAL DISORDERS. IT DOES NOT ADMIT CHILDREN FOR ANY DIAGNOSES OUTSIDE OF THESE AREAS AND DOES NOT OFFER MEDICAL SERVICES BEYOND THOSE NECESSARY TO CARE FOR CHILDREN WITH THESE DISEASES. OUR CANCER PATIENTS COME FROM ALL OVER THE UNITED STATES AND ABROAD; HOWEVER, 65% OF THE NEW CANCER PATIENTS WE REGISTER RESIDE IN THE ST. JUDE CATCHMENT AREA, WHICH INCLUDES A 180-MILE RADIUS AROUND ST. JUDE LOCATED IN MEMPHIS, TN AND A 100-MILE RADIUS AROUND EACH OF OUR EIGHT AFFILIATES. THESE EIGHT AFFILIATES ARE IN HUNTSVILLE, AL, CHARLOTTE, NC, JOHNSON CITY, TN, BATON ROUGE, LA, SHREVEPORT, LA, TULSA, OK, SPRINGFIELD, MO, AND PEORIA, IL. THE CATCHMENT POPULATION IS GENERALLY CHARACTERIZED BY A HIGHER PROPORTION OF NON-HISPANIC BLACK/AFRICAN AMERICAN RACE, LOWER PROPORTION OF HISPANIC ETHNICITY, LOWER HOUSEHOLD INCOMES AND HOME VALUES, AND LOWER PROPORTION WITH AN EDUCATION BEYOND HIGH SCHOOL. APPROXIMATELY 4.9% OF THE POPULATION LIVE IN RURAL AREAS (BY RUCA CODE 10). TAKEN TOGETHER, THIS DIVERSE POPULATION INCLUDES MANY WITH LIMITED RESOURCES WHO ARE MEDICALLY UNDERSERVED. THROUGH ST. JUDE'S FOUNDING POLICY - THAT NO PATIENT BE DENIED TREATMENT BASED ON RACE, ETHNICITY, RELIGION, OR A FAMILY'S INABILITY TO PAY - AND WITH THE PROVISION OF RESOURCES TO OFFSET THE COSTS OF TRANSPORTATION AND HOUSING DURING CLINIC VISITS AND TREATMENT, WE REMOVE BARRIERS IN ACCESS TO OUR CUTTING-EDGE CLINICAL RESEARCH TRIALS AND EXCEPTIONAL CLINICAL CARE. ALL PEDIATRIC PATIENTS IN OUR CATCHMENT AREA ARE ACCEPTED TO ST. JUDE FOR TREATMENT OF THEIR CANCER.THE DEMOGRAPHICS OF THE PEDIATRIC CANCER POPULATION TREATED AT ST. JUDE CLOSELY MATCH THOSE OF OUR CATCHMENT AREA (BASED ON 2010 DATA FROM THE US CENSUS BUREAU) AND ALIGN WITH THE ESTIMATED INCIDENCE OF PEDIATRIC CANCER IN REPRESENTED RACIAL AND ETHNIC GROUPS (BASED ON SURVEILLANCE EPIDEMIOLOGY AND END RESULTS [SEER] 2009 DATA), CONFIRMING THAT ST. JUDE IS CLOSELY ALIGNED WITH THE NEEDS OF THE POPULATION IT SERVES. DEMOGRAPHICS FROM THE ST. JUDE PEDIATRIC CANCER COHORT ARE COMPARED WITH THE DEMOGRAPHICS OF THE CATCHMENT AREA ANNUALLY TO MONITOR DEMOGRAPHIC REPRESENTATION OF OUR CANCER PATIENTS IN RELATION TO THE AREA THAT WE SERVE. ST. JUDE ALSO OPERATES THE ST. JUDE GLOBAL INITIATIVE THROUGH GLOBAL PEDIATRIC MEDICINE (GPM), AIMED AT IMPROVING SURVIVAL RATES OF CHILDREN WITH CANCER AND OTHER CATASTROPHIC DISEASES WORLDWIDE. ST. JUDE ACCOMPLISHES THIS BY SHARING KNOWLEDGE, TECHNOLOGY AND ORGANIZATIONAL SKILLS, IMPLEMENTING NEW APPROACHES TO TREAT PEDIATRIC CANCER GLOBALLY, AND GENERATING INTERNATIONAL NETWORKS COMMITTED TO ERADICATING CANCER IN CHILDREN. ST. JUDE STRIVES TO ADDRESS THE NEEDS OF THOSE CHILDREN IN COUNTRIES THAT LACK SUFFICIENT RESOURCES AND HELP THEM MANAGE THEIR OWN BURDEN OF CASES EFFECTIVELY.THE ST. JUDE GLOBAL ALLIANCE IS A GLOBAL NETWORK ESTABLISHED TO PURSUE THE SHARED VISION OF IMPROVING THE QUALITY OF HEALTH CARE DELIVERY AND INCREASING SURVIVAL RATES OF CHILDREN WITH CANCER AND BLOOD DISORDERS WORLDWIDE. CURRENTLY, THE ALLIANCE HAS RECEIVED APPLICATIONS FROM 196 MEDICAL INSTITUTIONS IN 64 COUNTRIES WITH ESTABLISHED PARTNERSHIPS WITH 147 OF THE MEDICAL INSTITUTIONS IN 61 COUNTRIES. MEMBERS OF THE ALLIANCE ARE A PART OF A GLOBAL COMMUNITY DEDICATED TO TRANSFORMING GLOBAL CHILD HEALTH. THEY WILL HAVE THE OPPORTUNITY TO DEVELOP GLOBAL PROJECTS AND STUDIES, CONNECT WITH COMMITTEES AND WORKING GROUPS AT THE REGIONAL AND GLOBAL LEVEL, AND ENGAGE WITH ST. JUDE FACULTY AND STAFF FOR TRAINING AND DEVELOPMENT. ALLIANCE MEMBER INSTITUTIONS IN THE FOLLOWING COUNTRIES RECEIVE ADDITIONAL SUPPORT FROM ST. JUDE FOR PROJECT IMPLEMENTATION IN BRAZIL, CHILE, CHINA, DOMINICAN REPUBLIC, ECUADOR, EL SALVADOR, GUATEMALA, HAITI, HONDURAS, JORDAN, LEBANON, MEXICO, MOZAMBIQUE, NICARAGUA, PERU, PHILIPPINES, POLAND, SOUTH AFRICA, URUGUAY, UKRAINE, URUGUAY, VENEZUELA, ZAMBIA AND ZIMBABWE. ST. JUDE WORKS WITH ITS PARTNERS TO DEVELOP EVIDENCE-BASED TREATMENT PROTOCOLS TAILORED TO REGIONAL NEEDS AND RESOURCES. ADDITIONALLY, ST. JUDE'S PHYSICIANS AND NURSES SERVE AS MENTORS TO CLINICAL PERSONNEL AT PARTNER SITES, PROVIDE LOCAL AND ONLINE TRAINING FOR ONCOLOGY CARE, DIAGNOSIS, AND SUPPORTIVE CARE, AND PARTICIPATE IN ONLINE MEETINGS TO DISCUSS CLINICAL CARE BEST PRACTICES. MOST ONLINE MEETINGS AND TRAINING ARE PROVIDED VIA ST. JUDE'S WEB-BASED PLATFORM, ST. JUDE CURE4KIDSTM (C4K), A FREE RESOURCE FOR PEDIATRIC ONCOLOGY PROFESSIONALS, SCIENTISTS AND RESEARCHERS, REGARDLESS OF THEIR AFFILIATION WITH ST. JUDE OR ITS PARTNERS.ST. JUDE IS ALSO A RESEARCH ORGANIZATION, WITH RESEARCH COVERING A BROADER SCOPE OF HEALTH ISSUES THAN THE DISEASES TREATED AS A PRIMARY DIAGNOSIS.

PART VI, LINE 5:
INSTITUTION OVERVIEWST. JUDE CHILDREN'S RESEARCH HOSPITAL WAS OPENED IN 1962. OUR MISSION IS TO ADVANCE CURES, AND MEANS OF PREVENTION, FOR PEDIATRIC CATASTROPHIC DISEASES THROUGH RESEARCH AND TREATMENT. CONSISTENT WITH THE VISION OF OUR FOUNDER, DANNY THOMAS, NO CHILD IS DENIED TREATMENT BASED ON RACE, RELIGION OR A FAMILY'S INABILITY TO PAY. OUR VISION IS TO BE THE WORLD LEADER IN ADVANCING THE TREATMENT AND PREVENTION OF CATASTROPHIC DISEASES IN CHILDREN. THIS VISION IS PURSUED BY PROVIDING OUTSTANDING PATIENT CARE; BY CONDUCTING BASIC, TRANSLATIONAL AND CLINICAL RESEARCH DESIGNED TO ELUCIDATE BIOLOGICAL MECHANISMS, UNDERSTAND DISEASE PATHOGENESIS, IMPROVE DIAGNOSIS, ENHANCE TREATMENT OUTCOME, PREVENT DISEASES AND MINIMIZE ADVERSE CONSEQUENCES OF TREATMENT; AND BY EDUCATING HEALTH CARE AND SCIENTIFIC RESEARCH PROFESSIONALS. THROUGH THESE EFFORTS, WE SEEK TO CURE AND ENHANCE THE QUALITY OF LIFE FOR AN INCREASING NUMBER OF CHILDREN WHO COME TO US FOR TREATMENT BY EXPANDING AND SHARING KNOWLEDGE TO ADVANCE TREATMENT OF CHILDREN WITH CATASTROPHIC DISEASES WORLDWIDE, WHILE DEVELOPING STRATEGIES TO PREVENT CATASTROPHIC DISEASES IN CHILDREN. WE ARE THE ONLY NCI-DESIGNATED CANCER CENTER SOLELY DEDICATED TO CHILDREN.ST. JUDE COMBINES LABORATORY AND CLINICAL RESEARCH TO ADVANCE THE CARE OF CHILDREN WITH CANCER AND OTHER CATASTROPHIC DISEASES. ST. JUDE IS COMMITTED TO LEVERAGING ITS ASSETS TO ACCELERATE PROGRESS AND MAXIMIZE IMPACT FOR CHILDREN IN MEMPHIS AND AROUND THE GLOBE WITH AN ACUTE FOCUS ON FUNDAMENTAL SCIENCE, CHILDHOOD CANCER, PEDIATRIC CATASTROPHIC DISEASES, GLOBAL IMPACT, AND WORKFORCE AND ENVIRONMENT. ST. JUDE HAS AND WILL CONTINUE TO SIGNIFICANTLY INFLUENCE THE WAY THE WORLD UNDERSTANDS AND TREATS CHILDHOOD CANCER, SICKLE CELL DISEASE, NEUROLOGICAL DISORDERS, AND INFECTIOUS DISEASES. THE ST. JUDE ENVIRONMENT FACILITATES INTERACTION AMONG LABORATORY SCIENTISTS AND CLINICAL INVESTIGATORS, PROMOTING THE TRANSLATION OF NEW FINDINGS FROM THE LAB TO THE CLINIC AND COMMUNICATING CLINICAL PROBLEMS TO LABORATORY SCIENTISTS FOR FURTHER INVESTIGATION. OUR 22 ACADEMIC DEPARTMENTS ARE HOME TO MORE THAN 120 FUNDAMENTAL AND TRANSLATIONAL RESEARCH LABS THAT BRING THE 'BENCH TO THE BEDSIDE,' ENSURING THAT PATIENTS TREATED AT ST. JUDE FULLY BENEFIT FROM ADVANCES IN OUR UNDERSTANDING OF PEDIATRIC CATASTROPHIC DISEASE AND THEIR TREATMENT.HOSPITAL OPERATIONS ARE OVERSEEN BY A BOARD OF GOVERNORS, MOST OF WHICH ARE NEITHER EMPLOYEES, INDEPENDENT CONTRACTORS, NOR THEIR FAMILY MEMBERS. RESEARCH ACTIVITIES ARE REVIEWED ANNUALLY BY A SCIENTIFIC ADVISORY BOARD COMPOSED OF INTERNATIONALLY PROMINENT PHYSICIANS AND SCIENTISTS. AN INSTITUTIONAL REVIEW BOARD, OR IRB, WHICH IS A GROUP OF SCIENTISTS, DOCTORS, OR OTHER HEALTH CARE PROFESSIONALS, REVIEWS EVERY NEW CLINICAL RESEARCH STUDY AT THE HOSPITAL BEFORE IT BEGINS.THE PRIMARY FUNDRAISING SOURCE FOR ST. JUDE IS ALSAC (AMERICAN LEBANESE AND SYRIAN ASSOCIATED CHARITIES), WHICH RAISES FUNDS SOLELY FOR THE HOSPITAL. BECAUSE OF THE HOSPITAL'S MISSION, PEOPLE NATIONWIDE CONTRIBUTE VIA TENS OF THOUSANDS OF FUNDRAISING EFFORTS. ALSAC CONTRIBUTED $997 MILLION IN FY22 TO SUPPORT ST. JUDE.FINDING CURES AND SAVING CHILDREN REMAINS AT THE FOREFRONT OF ALL WE DO. OUR FACULTY AND STAFF KNOW ALL TOO WELL THAT CANCER AND OTHER DEADLY ILLNESSES DON'T STOP, EVEN IN THE MIDST OF A PANDEMIC AND UPHEAVAL ON THE WORLD STAGE. AS A RESULT, WE CONTINUE TO CARE FOR THOUSANDS OF CHILDREN WITH CANCER AND OTHER LIFE-THREATENING DISEASES. WE ARE FOCUSED ON ENSURING PATIENTS GET THE TREATMENT THEY NEED AND UNDERSTANDING THE SCIENTIFIC FOUNDATION THROUGH BASIC AND TRANSLATIONAL RESEARCH, CLINICAL TRIALS, AND POPULATION SCIENCE FOCUSED ON CATASTROPHIC CHILDHOOD DISEASES AND SURVIVORSHIP. (NOTE: THIS NARRATIVE FOR PART VI, LINE 5 IS CONTINUED BELOW) - SEE PAGE 87/115

PART VI, LINE 2 (CONTINUATION FROM 80/115)
HIVTHE CONNECT TO PROTECT (C2P) COMMUNITY COALITION LED BY MEMBERS OF THE HOSPITAL'S COMPREHENSIVE HIV PREVENTION AND TREATMENT PROGRAM FOR CHILDREN AND YOUTH, HAS SIGNIFICANTLY CONTRIBUTED TO THE STRONG COMMUNITY TIES THAT ST. JUDE HAS ESTABLISHED AND STRENGTHENED. LAUNCHED IN 2008, C2P IS MADE UP OF 25 PARTNER AGENCIES REPRESENTING A DIVERSE MIX OF STAKEHOLDERS FROM VARIOUS SECTORS IN MEMPHIS. THIS INCLUDES THE HEALTH DEPARTMENT, FAITH-AND COMMUNITY-BASED ORGANIZATIONS, SCHOOLS, BUSINESSES, YOUTH, AND HEALTH CARE ORGANIZATIONS; ALL ALIGNED WITH THE COMMON GOAL OF OPTIMIZING HIV PREVENTION AND TREATMENT. THE STRENGTH OF THIS COALITION HAS BEEN TO PROVIDE A NON-THREATENING, COLLABORATIVE ENVIRONMENT WHERE INDIVIDUALS AND AGENCIES WITH DIFFERENT BACKGROUNDS AND PRIORITIES HAVE BEEN ABLE TO COLLABORATIVELY IMPLEMENT OVER 70 NEW POLICIES, PRACTICES AND PROGRAMS THAT IMPACT HIV PREVENTION AND TREATMENT IN YOUTH. IN THIS COALITION, WE HAVE LEARNED AND SHARED BEST PRACTICES, RESEARCH METHODOLOGIES, AND TOGETHER, IDENTIFIED AND DEVELOPED NEW STRUCTURAL CHANGE OBJECTIVES TO ADDRESS IMPEDIMENTS THAT PREVENT YOUTH FROM MOVING ALONG THE HIV PREVENTION AND TREATMENT CARE CONTINUUM. WITHIN THIS 2022 FISCAL YEAR AND WORKING IN THE MIDST OF THE PANDEMIC, STAFF PIVOTED FROM IN-PERSON TO VIRTUAL MEETING PLATFORM AND COORDINATED AND HOSTED MULTIPLE C2P VIRTUAL MEETINGS FOR THE 25 MEMBER ORGANIZATIONS OF THE CONNECT TO PROTECT (C2P) COMMUNITY COALITION. THE HIV PREVENTION AND TREATMENT PROGRAM VALUES THE STRONG AND BI-DIRECTIONAL COLLABORATION WITH COLLEAGUES IN THE COMMUNITY. WITH A SHARED FOCUS, WE HAVE BEEN ABLE TO ACHIEVE LINKAGE TO CARE, RETENTION IN CARE AND PREP EFFORTS, THROUGH COMMUNITY AGENCY BUY-IN AND SUPPORT.

PART VI, LINE 5 (CONTINUATION FROM PAGE 86/115)
FACILITIESFOR FY22, ST. JUDE ANNOUNCED AN EXPANSION OF ITS SIX-YEAR STRATEGIC PLAN THAT WILL NOW COMMIT $12.9 BILLION TO SUPPORT 2,300 JOBS AND INCREASE FUNDS FOR CONSTRUCTION, RENOVATION AND CAPITAL NEEDS. THE NEW FUNDING WILL AFFECT SCIENTIFIC OPERATIONS, CLINICAL CARE, GLOBAL MEDICINE AND INFRASTRUCTURE. THE EXPANSION WILL INCLUDE CONSTRUCTION OF TWO, 15-STORY TOWERS DEDICATED TO PATIENT CARE AND CLINICAL RESEARCH. A NEW HOUSING COMPLEX IS UNDER CONSTRUCTION AS IS A 45,000SF TREATMENT-AND-STAFF-FREE FLOOR AT THE HOSPITAL WHERE PATIENTS AND THEIR FAMILIES CAN GATHER, RELAX, ATTEND SCHOOL, PLAY MUSIC, NAP, OR GRAB A CUP OF COFFEE IN BETWEEN CLINIC APPOINTMENTS.LASTLY, TO ENHANCE THE PATIENT EXPERIENCE AT ST. JUDE, THE INSTITUTION HAS CREATED IN PARTNERSHIP WITH THE MEMPHIS-SHELBY COUNTY AIRPORT AUTHORITY, A PRIVATE, COMFORTABLE SPACE FOR PATIENTS AND THEIR FAMILIES TO WAIT FOR THEIR FLIGHT OR TRANSPORTATION TO THE CAMPUS. THESE PROJECTS FOLLOW THE 2021 OPENING OF THE INSPIRATION4 ADVANCED RESEARCH CENTER THAT WILL ACCOMMODATE UP TO 1,000 EMPLOYEES FOCUSED ON TRANSFORMATIVE SCIENCE. THE STRUCTURE IS DESIGNED FOR COLLABORATION ACROSS MANY SCIENTIFIC FIELDS, INCLUDING DEVELOPMENTAL NEUROBIOLOGY, IMMUNOLOGY, CELL AND MOLECULAR BIOLOGY, GENE EDITING, METABOLOMICS, ADVANCED MICROSCOPY, EPIGENETICS AND GENOMICS. IT IS ALSO HOME SO SPECIALIZED TECHNOLOGY FOR CONDUCTING COMPUTATIONAL BIOLOGY, USING ARTIFICIAL INTELLIGENCE, GENE EDITING AND ANALYZING CELL SAMPLES VIA SOME OF THE WORLD'S MOST ADVANCED MICROSCOPES. A BIOREPOSITORY ON SITE CONTAINS TUMOR SAMPLES FOR SHARING WITH RESEARCHERS AROUND THE WORLD.THESE INVESTMENTS ARE PART OF A RICH HISTORY. ST. JUDE CONTRIBUTED TO THE BUILDING OF A STATE-OF-THE ART NEUROSURGICAL FACILITY FOR TREATING LOCAL PEDIATRIC PATIENTS AND ST. JUDE BRAIN TUMOR PATIENTS. THE FACILITY IS EQUIPPED WITH INTRA-OPERATIVE IMAGING EQUIPMENT (IMRI). WHEN PURCHASED, ONLY TWO NEUROSURGICAL FACILITIES IN THE UNITED STATES PROVIDED PATIENTS WITH THIS LEVEL OF TREATMENT, WHICH ALLOWS IMAGING TO TAKE PLACE DURING SURGICAL PROCEDURES. IMRI EQUIPMENT ALLOWS SURGEONS TO MAKE INFORMED DECISIONS DURING THE SURGERY. LIVE WEB CASTS ALLOW OTHERS TO VIEW PROCEDURES. OUR ASSISTANCE WITH THIS FACILITY HELPS ASSURE THAT CHILDREN IN THE AREA HAVE ACCESS TO THE BEST NEUROSURGICAL TREATMENT AVAILABLE.THE CYCLOTRON (PARTICLE ACCELERATOR) AT ST. JUDE ENABLES RESEARCHERS TO TRACK THE GROWTH OF CANCER CELLS, PINPOINT THE PRODUCTION OF NEW DNA BY TUMOR CELLS AND STUDY THE HEARTS OF ADULT CHILDHOOD CANCER SURVIVORS RETURNING TO ST. JUDE FOR LIFETIME FOLLOW-UP. THE CYCLOTRON HELPS RESEARCHERS BETTER UNDERSTAND CHILDHOOD CANCER BY ENABLING THEM TO PRODUCE NEW, VERY SHORT-ACTING TRACERS.ST. JUDE USES THE SERVICES OF CHILDREN'S GMP, LLC (OF WHICH ST. JUDE IS THE SOLE MEMBER). CHILDREN'S GMP, LLC, MANAGES AND OPERATES A GOOD MANUFACTURING PRACTICE (GMP) FACILITY THAT ENGAGES IN THE PRODUCTION OF BIOLOGICS AND DRUGS FOR RESEARCH. THE GMP OFFERS RESOURCES TO STUDY RARE DISEASES OVERLOOKED BY PHARMACEUTICAL COMPANIES BECAUSE THERE IS LITTLE PROFIT IN MANUFACTURING DRUGS FOR LESSER-KNOWN DISEASES. THE FACILITY, OPERATING ACCORDING TO APPROVED FDA STANDARDS, ALLOWS DOCTORS TO TAILOR TREATMENTS SPECIFICALLY FOR AN INDIVIDUAL CHILD.THE CELL AND TISSUE IMAGING CENTER INCLUDES ELECTRON MICROSCOPY AND LIGHT MICROSCOPY. THE FACILITY PROVIDES INVESTIGATORS ACCESS TO TRANSMISSION ELECTRON MICROSCOPY, CONFOCAL LASER SCANNING MICROSCOPY, MULTIPHOTON MICROSCOPY, IMAGE ANALYSIS, CELL MICROINJECTION AND LIVE CELL IMAGING. THE FEI TECNAI 20 200KV FEG ELECTRON MICROSCOPE, WHICH CAN MAGNIFY AN OBJECT 700,000 TIMES, IS AT THE HEART OF THIS PROGRAM. THIS TECHNOLOGY ALLOWS RESEARCHERS TO GET A CLOSER LOOK AT CANCER TO BETTER UNDERSTAND HOW IT GROWS AND SPREADS AND RESPONDS TO THERAPY. USING THE ELECTRON MICROSCOPE, RESEARCHERS LEARN HOW CANCER CELLS BREAK AWAY FROM THE TUMOR AND SPREAD THROUGHOUT THE BODY.ST. JUDE IS HOME TO THE ONLY PROTON BEAM RADIATION THERAPY CENTER DEVOTED SOLELY TO TREATING CHILDREN WITH BRAIN TUMORS AND SEVERAL OTHER CHILDHOOD CANCERS. PROTON THERAPY, WHICH IS LESS DAMAGING TO SURROUNDING HEALTHY TISSUE THAN OTHER CURRENT RADIATION THERAPIES, ENABLES ST. JUDE TO PROVIDE RADIATION IN A MORE INTEGRATED MANNER TO OUTPATIENTS AND ALLOWS RADIATION ONCOLOGISTS TO LEAD THE DEVELOPMENT OF NEW TREATMENTS.

RESEARCH
ST. JUDE SCIENTISTS CONTINUED TO TRAVEL THEIR PATH OF INNOVATION, MAKING DISCOVERIES AND SHARING THEIR FINDINGS WITH THE WORLD. IN 2022, ST. JUDE LEAD AUTHORS PUBLISHED 115 HIGH-IMPACT (>10) PEER REVIEWED PAPERS. THE ARTICLES FOCUSED ON A BROAD SWATH OF BASIC AND CLINICAL RESEARCH. SOME HIGHLIGHTS INCLUDE:CANCER SURVIVORSHIP IN THE ERA OF BIG DATA. ST. JUDE IS A POWERHOUSE WHEN IT COMES TO LEVERAGING VAST AMOUNTS OF DATA TO BETTER UNDERSTAND CANCER. THAT POWER, COMBINED WITH FIELD LEADING EXPERTISE IN SURVIVORSHIP AND ACCESS TO THE WORLD'S FINEST COLLECTIONS OF SURVIVORSHIP DATA THROUGH ST. JUDE LIFE AND THE CHILDHOOD CANCER SURVIVORS STUDY HAS SET ST. JUDE UP TO MAKE DISCOVERIES ABOUT THE HEALTH AND LIVES OF CHILDHOOD CANCER SURVIVORS THAT COULD NOT BE MADE ANYWHERE ELSE. RESEARCH IN 2022 HAS DUG INTO ISSUES SUCH AS ANCESTRY AND INHERITED RISK, SOCIOECONOMIC DISPARITIES, AND MORE USING LARGE-SCALE DATA ANALYSIS AND INFORMATICS. (LEE ET AL, JAMA ONCOLOGY, 3/1/22; DONG ET AL, GENOME MED, 3/22/22; WILLIAMS ET AL, BLOOD, 5/19/22; SAPKOTA ET AL, NATURE MED, 8/1/22; IM ET AL, CANCER RESEARCH 8/16/23; SHIN ET AL, J CLIN ONC, 9/27/22; SONG ET AL, CANCER COMMUN, 10/18/22; WANG ET AL, CANCER RES, 11/10/22)GENE REGULATION: THE NEXT FRONTIER OF DISCOVERY IN PEDIATRIC CANCER. ST. JUDE LED THE CHARGE TO UNDERSTAND THAT GENETICS OF PEDIATRIC CANCER THROUGH THE PEDIATRIC CANCER GENOME PROJECT (PCGP). WHILE MUCH WAS LEARNED FROM THE PCGP, ONE OF THE MAIN LEARNINGS WAS THAT PEDIATRIC CANCER IS INCREDIBLY COMPLEX, AND MANY ABNORMALITIES AND MUTATIONS LIE IN PLACES WITHIN THE GENOME THAT ARE TIED TO ENHANCER AND SUPER-ENHANCER BIOLOGY AND NON-CODING GENOME REGULATION. SCIENTISTS AT ST. JUDE ARE ONCE AGAIN ON THE LEADING EDGE OF DISCOVERY, DIGGING THROUGH THE BIOLOGY OF CANCER CELLS TO UNDERSTAND HOW GENES ARE CONTROLLED AND EXPRESSED AND IDENTIFY POTENTIAL VULNERABILITIES AND WEAKNESSES THAT CAN BE EXPLOITED BY THERAPY. (YANG ET AL, NAT GENET, 2/1/22; DURBIN ET AL, CANCER DISCOVERY, 3/1/22; CHANDRA ET AL, CANCER DISC, 4/1/22; FLASCH ET AL, ACTA NEUROPATH, 5/1/22; HETZEL ET AL, NATURE CANCER, 6/1/22; FLERLAGE ET AL, BLOOD, 8/17/22; HU ET AL, SCI TRANS MED, 8/24/22; ZHAO ET AL, J NCI, 9/9/22; ZHAO ET AL, NAT COMMUN, 9/14/22)CAR T CELLS: ENGINEERING A BREAKTHROUGH. THERE IS TREMENDOUS MOMENTUM BEHIND THE IDEA OF MODULATING THE IMMUNE SYSTEM TO ATTACK CANCER, WITH GREAT SUCCESS ALREADY DEMONSTRATED IN SOME SETTINGS FOR CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS. YET THE TRUE PROMISE OF CAR T CELLS HAS YET TO BE REALIZED, ESPECIALLY IN DISEASES LIKE AML, SOLID TUMORS AND BRAIN TUMORS. SCIENTISTS AT ST. JUDE ARE LEADING THE CHARGE TO UNDERSTAND THE FUNDAMENTAL BIOLOGY OF CAR T CELLS, IDENTIFY THE OPTIMAL TARGETS AND DESIGN AND ENGINEER THE NEXT GENERATION OF CAR T CELLS FOR THESE HARDER TO TREAT TYPES OF PEDIATRIC CANCER. (HEBBAR ET AL, NAT COMMUN, 1/31/22; VAIDYA ET AL, HAEMATOLOGICA, 7/28/22; FREIWAN ET AL, BLOOD, 8/1/22; CARNEVALE ET AL, NATURE, 9/1/22; WILSON ET AL, CANCER DISC, 9/2/22)RETHINKING THE ROLE OF RADIATION THERAPY. RADIATION IS A CORNERSTONE OF CARE FOR MANY TYPES OF PEDIATRIC CANCER. WHILE THERE HAS BEEN A TREMENDOUS AMOUNT OF RESEARCH AROUND HOW TO GIVE RADIATION SAFELY AND OPTIMIZE RESULTS, SCIENTISTS AT ST. JUDE ARE SETTING THE GOLD STANDARD WHEN IT COMES TO STUDYING AND UNDERSTANDING RADIATION THERAPY, DEMONSTRATING ITS IMPORTANCE FOR THERAPY, AND PROVIDING FIELD-SHAPING RECOMMENDATIONS ABOUT HOW TO BEST USE THIS THERAPY. RESEARCHERS HAVE PARTICULARLY FOCUSED ON DIFFICULT TO TREAT AND RARE DISEASES SUCH AS CRANIOPHARYNGIOMA, DEMONSTRATING HOW RADIATION THERAPY CAN HELP DRIVE CURE RATES. (EDMONSTON ET AL, NEURO ONCOL, 12/1/22; MERCHANT ET AL, NEURO ONCOL, 12/1/22; JACOLA ET AL, J CLIN ONCOL, 11/2/22; LIU ET AL, ACTA NEUROPATH, 10/1/22; LUCAS ET AL, NEURO ONC, 7/1/22; ACAHRYA ET AL, J CLIN ONC, 1/1/22)LEVERAGING TECHNOLOGY TO UNDERSTAND BIOLOGICAL STRUCTURE AND FUNCTION. ST. JUDE HAS BUILT INFRASTRUCTURE TO CONDUCT RESEARCH THAT LOOKS AT THE BIOLOGIC STRUCTURE OF PROTEINS AND MOLECULES AT THE MOST INTRICATE, DETAILED LEVELS. WITH TECHNIQUES SUCH AS SINGLE-MOLECULE IMAGING LEADING THE FOREFRONT OF TECHNOLOGICAL INNOVATION, AND MAINSTAYS LIKE CRYO-EM CONTINUING TO PUSH THE ENVELOPE, SCIENTISTS AT ST. JUDE ARE CONTINUALLY MAKING DISCOVERIES THAT SHAPE OUR UNDERSTANDING OF THE MOST FUNDAMENTAL BIOLOGIC PROCESSES. (ASHER ET AL, CELL, 5/12/22; YE ET AL, MOL CELL, 7/7/22; STACHOWSKI ET AL, ANGEW CHEM INT, 8/1/22; UGOLINI ET AL, MOL CELL, 11/16/22; SANDHU ET AL, NAT COMMUN, 12/2/22)